The Binding of Isaac: Rebirth – Pandora’s Box Effects

The Binding of Isaac: Rebirth – Pandora’s Box Effects 1 - wpgameplay.com
The Binding of Isaac: Rebirth – Pandora’s Box Effects 1 - wpgameplay.com

Guide for The Binding of Isaac: Rebirth – Pandora’s Box Effects

Two simple tables you can refer to when finding Pandora’s Box in your run, plus some information and intricacies of using it. Covers Normal/Hard difficulties as well as Greed/Greedier mode.

Just a little something for myself, since I always find myself having to open a tab of the Isaac wiki whenever I find Pandora’s Box. Might as well publish it, since some existing guides on Steam seem to be missing information or DLC changes. Side note: Favouriting a guide will mean that it will always show up first in the Guides subcategory of your Steam in-game overlay (the shift+tab menu), so if you wish to have quick access to this guide or some other helpful guide, give it a favourite!

Effects in Normal/Hard Mode:

 

Chapter Title Alt Floors in this ChapterFloor NumberRewards
Chapter 1: The BasementBasement, Cellar, Burning Basement, Downpour, Dross1st or XL floor2 soul hearts
2nd floor2 bombs and 2 keys
Chapter 2: The CavesCaves, Catacombs, Flooded Caves, Mines, Ashpit1st or XL floor1 Boss Room item
2nd floor1 Boss Room item and 2 soul hearts
Chapter 3: The DepthsDepths, Necropolis, Dank Depths, Mausoleum, Gehenna1st or XL floor4 soul hearts
2nd floor20 coins
Chapter 4: The WombWomb, Utero, Scarred Womb, Corpse1st or XL floor2 Boss Room items
2nd floorThe Bible
Chapter 5a: Cathedraln/an/a1 Angel Deal item and 1 eternal heart
Chapter 6a: The Chestn/an/a1 penny
Chapter 5b: Sheoln/an/a1 Devil Deal item and 1 black heart
Chapter 6b: Dark Roomn/an/aUnlocks Moving Box in Afterbirth+, otherwise nothing
??? (Blue Womb)n/an/aNothing
The Voidn/an/aNothing
Final Chapter: Homen/an/aRed Key

 
 

Effects in Greed/Greedier Mode:

 

Chapter Title Alt FloorsRewards
Chapter 1: The BasementBasement, Cellar, Burning Basement2 bombs and 2 keys
Chapter 2: The CavesCaves, Catacombs, Flooded Caves1 Boss Room item and 2 soul hearts
Chapter 3: The DepthsDepths, Necropolis, Dank Depths20 coins
Chapter 4: The WombWomb, Utero, Scarred Womb2 Boss Room items
Chapter 5: Sheoln/a1 Devil Deal item and 1 black heart
Chapter 6: The Shopn/a1 penny
Final Chapter: Ultra Greedn/a1 penny

 
 

Important Information

 

The basics of Pandora’s Box (if you’re already familiar with the item, you can skip this)

The finer details of Pandora’s Box

  • When on an XL Floor because of Curse of the Labyrinth, refer to the first floor of your current chapter. 
  • The Afterbirth passive item bindingofisaacrebirth.fandom.com – https://bindingofisaacrebirth.fandom.com/wiki/Car_Battery does not double the reward gained from using Pandora’s Box, no matter what floor you’re on. 
  • With the Repentance DLC loaded, the consumable bindingofisaacrebirth.fandom.com – https://bindingofisaacrebirth.fandom.com/wiki/%3F_Card will not consume single use active items such as Pandora’s Box, meaning you can consume the card to gain a reward for the current floor without consuming Pandora’s Box. Keep in mind that if you do not have Repentance active/installed, using the ? Card will just consume the box as if you had used it normally. 
  • With one exception, Pandora’s Box calls items from a set item pool when used on floors that would make it spawn a pedestal item, e.g. Boss reward pool, Devil deal pool or Angel deal pool. That said, if the item pool Pandora’s Box tries to use has already been exhausted, it will instead spawn an item from the Treasure Room item pool. You will rarely be in a situation where an entire item pool has been exhausted, though, so don’t try to incorporate this into your strategy when you find a box. 
  • The exception to the item pool rule listed above is when the user is holding the bindingofisaacrebirth.fandom.com – https://bindingofisaacrebirth.fandom.com/wiki/Strange_Key in their trinket slot (Repentance trinket, unlocked by beating Cathedral, The Chest, Sheol and Dark Room as Tainted Eve ). With the trinket in tow, the current floor’s listed effect is ignored completely and 6 items from randomly selected pools will be spawned instead, consuming both the box and the Strange Key. 
  • It is important to note that when Pandora’s Box spawns items, the spawned items are placed on pedestals around the player and remain there. Therefore, if the box spawns ‘bad’ items or items you don’t wish to take, you can choose not to pick them up and instead reroll or void absorb them if given the chance (a good strategy if you lack the necessary items is to open the box in a room with a reroll machine already inside). However, remember that even though Pandora’s Box pulls from the pools of either Boss Rewards, Angel Deals or Devil Deals, rerolling an item pedestal pulls from the pool of the room they’re currently in (for non-special rooms, the Treasure Room pool is used), so you can’t expect to reroll an item into another of the same pool unless you’re in the same room that pool exists in.

An example of ??? finding Pandora’s Box on the first floor curse room.

The Binding of Isaac: Rebirth - Pandora's Box Effects 
 

By avii

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